Ibuprofen alters human testicular physiology

Discussion in 'Off-topic' started by Malum Prohibitum, Jan 10, 2018.

  1. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    Concern has been raised over declining male reproductive health in humans. Our study addresses this issue by extending data showing antiandrogen effects of analgesics and suggests that such compounds may be involved in adult male reproductive problems.

    Using a unique combination of a randomized, controlled clinical trial and ex vivo and in vitro approaches, we report a univocal depression of important aspects of testicular function, including testosterone production, after use of over-the-counter ibuprofen.

    The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis.

    This repression results in the elevation of the stimulatory pituitary hormones, resulting in a state of compensated hypogonadism, a disorder associated with adverse reproductive and physical health disorders.

    http://www.pnas.org/content/early/2018/01/03/1715035115
     
  2. moe mensale

    moe mensale Well-Known Member

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    That study is nuts.
     
    RedDawnTheMusical and 55MPHX4 like this.

  3. Nemo

    Nemo Man of Myth and Legend

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    Thats what they were studying for sure.

    Nemo
     
    Savannah Dan likes this.
  4. AtlPhilip

    AtlPhilip Proud GCO member.

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    Well, it is a good thing I am past childbearing age...
     
  5. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    More than fertility is affected.
     
  6. Mrs_Esterhouse

    Mrs_Esterhouse Swollen Member

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    These studies are really only relevant for guys taking ibuprofen on a daily basis.

    A guy that takes a dose or two of Advil every couple of months for an acute headache or sinus pain, is pretty much not impacted by the drug at all.
     
    janedoedad likes this.
  7. AtlPhilip

    AtlPhilip Proud GCO member.

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    "previous study reported androsterone levels decreased by 63% among men receiving 400 mg of ibuprofen every 6 h for 4 wk"

    I didn't read the study that deeply. Did it recover afterward?
     
  8. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    That was a comment on a previous study. That is how studies are written. Others have looked at x, y, and z. The outcomes were a, b, and c. Now we are looking at either confirming these or explaining why or looking at some aspect that x, y, and z did not cover.
     
  9. jreXD9

    jreXD9 Active Member

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    they actually had the balls to print that.