Hopeful and Faith Is Not a Manufacturing Plan

Discussion in 'Off-topic Political' started by Malum Prohibitum, Jan 9, 2021.

  1. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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  2. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    But Azar said Friday that he worries that might backfire if manufacturing goes wrong.
    "We have product that is going through QC right now -- quality control -- for sterility, identity check -- that -- we have tens and tens of millions of product. We always will. But batches fail. Sterility fails. ... And then you don't have a product for that second dose," Azar told the American Hospital Association, according to a transcript released by HHS.

    "And frankly, talking about that or encouraging that can really undermine a critical public health need, which is that people come back for their second vaccine," he said.

    https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html
     

  3. moe mensale

    moe mensale Well-Known Member

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    Add "bet" to "hope" and "faith."
     
  4. moe mensale

    moe mensale Well-Known Member

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    This is but one example of why "Harris/Biden" is going to crash and burn just in time for the 2022 midterms.
     
    blind_shake and Phil1979 like this.
  5. NTA

    NTA Well-Known Member

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    Media will declare this is just following the science. Fauchi will get on board.

    This is the first major screw up of a demented old fellow. Have you noticed his TV appearances that involve numbers, he always screws up the numbers. That's one of the first things to go. I've witnessed that with my dad who was very verbal and intelligent sounding.

    Two banks kicked him out for hanging around their lobby all day asking for printouts of his balance. Then claiming they were stealing from him. Could not understand the bank receipt, tell time, or read a calendar. Good in most all other respects.
     
    Jonathan Freeman likes this.
  6. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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  7. Craftsman

    Craftsman Well-Known Member

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    A few more facts.

    Single dose has SOME efficacy. Not as much as two doses, but a significant amount. Basic principle of "something is better than nothing".

    Storage of unused vaccine has risks. Field refrigeration units have non-zero failure rates. Handling errors can result in spoilage. Nothing is zero-risk.

    Additional time between doses does not seem to affect the final efficacy. So if the second dose is delayed, there are zero net negative consequences for the population at large.

    Manufacturing failures are generally in the batch lot unit, seldom do you lose weeks of production without catching on. This is true on almost all modern continuous manufacturing processes. Statistically, the odds of losing a month's production are insignificantly low.

    Producers are ramping up production to the maximum their facilities can safely produce. This means more doses will be available on future dates than now.

    So, this is actually a very good plan to get more vaccine into the arms of the general public as fast as possible. Planning at scale means minimizing risk. This plan is does exactly that.
     
  8. phantoms

    phantoms Senior Mumbler

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  9. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    My understanding is that the studies did not look at second doses outside of a certain window, so do you have new studies to back up this assertion that the second shot can be later?

    In addition, the studies did not look at efficacy of one dose. They DID look at the number of antibodies in a window before the second dose, but there are not trials on one-dose recipients, so the "some efficacy" is not, to my knowledge, based on any science, but rather just hope from politicians that having some antibody response two weeks after the first shot will be "effective." There is not a cohort of one-shot vaccine receivers to compare and see the results. Again, do you have studies not he efficacy of one shot for any of the vaccines?
     
  10. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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    Weird. They say it is intentional, but they do not know a motive. Without a motive, why is it not just negligence? How do they know? Did the pharmacist admit it, oh, yeah, I meant to spoil 500 doses?

    Why?

    I ain't telling you!

    That does not seem likely.
     
  11. Craftsman

    Craftsman Well-Known Member

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    I recall (haven't had time to dig) that some of the trials involved one dose vs. two dose regimens and that is how they arrived at the two dose number. Same for fixing the minimum dose interval. When they went back and gave second doses at the end of the trial to the test subjects, they ended up with the same immune response as folks who had the second dose at the minimum interval.
     
  12. Malum Prohibitum

    Malum Prohibitum Moderator Staff Member

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  13. Craftsman

    Craftsman Well-Known Member

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    This country and much of the world has run on JIT inventory for decades now. While there are occasional glitches, it generally works. Plus there are more folks versed in managing that type of supply chains than with "traditional" supply chains.