It's a fair question, and yet another question that nobody has an answer to at the present. As we discover more in the future, I might decide that the risk/reward calculus warrants receiving an mRNA therapy. But given that you can't un-take such therapies, I'm erring on the side of not having one now, but I won't preclude the possibility in the future.So you're concerned about the (unknown) long-term impacts of MRNA vaccines. Okay. But what are the long-term impacts of COVID to your body? I totally support everyone making their own decision, but you should weigh the risks on both sides of the equation, both short and long-term.
Do we really want to go there?One other thought, only tangentially associated with epidemiology.
What plans do politicians have for individuals who have survived a full-blown COVID infection and have recovered? Their immune systems will now carry antibodies to combat future infections of (at least) that variant of COVID. They should have a similar level of immunity to a subsequent infection from the same/similar COVID variants. Do they get some paperwork to show people that they're "safe" when they're challenged by whoever is going to inspect these 'passports'?
If not, why not?
One can live in a population density of 1 person per square mile with a 1% per month population turnover and take their own liberties in the act of fecal disposal with practically zero chance of killing or sickening another human. This luxury does not exist at a population density of 10,000 people per square mile. The same principle applies to exposure, infection, quarantine, vaccinations, and herd immunity.
It will certainly be an interesting civil rights discussion for the coming century as density discussions move from acres per person to cubic feet per person. The individual deserves the right to opt out...out of the vaccine and mask wearing as well as out of utilization of the public square if that is determined to be the mandate via public policy.So forced masking, forced vaccinations, forced passport for any travel outside your neighborhood, forced passport to enter businesses, forced business closings, forced church closings, forced ban on family gatherings at your own home, are all good then? That is, if you happen to live in a population dense area. Such power must give those who have it quite a head rush. Where can I get some of it?
And herd immunity is a pipe dream. Is there herd immunity for common flu viruses? No. Too many variants. And aren't we hearing that new variants are occurring with COVID? This is never going away. Quite a boon for those in power, no?
March 5, ,2021We show here that S protein alone can damage vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis. The underlying mechanism involves S protein downregulation of AMPK and upregulation of MDM2, causing ACE2 destabilization. Thus, the S protein-exerted vascular endothelial damage via ACE2 downregulation overrides the decreased virus infectivity.
April 27, 2021One of the most important pathologies, is hypercoagulation and microclots in the lungs of patients. Here we study the effect of isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen sui generis. Using scanning electron and fluorescence microscopy as well as mass spectrometry, we investigate the potential of this inflammagen to interact with platelets and fibrin(ogen) directly to cause blood hypercoagulation. Using platelet poor plasma (PPP), we show that spike protein may interfere with blood flow.
April 30, 2021Using a newly developed mouse model of acute lung injury, researchers found that exposure to the SARS-CoV-2 spike protein alone was enough to induce COVID-19-like symptoms including severe inflammation of the lungs.
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.