At least, not according to the FBI... Small pistol. Large pistol. Huge pistol. Rifle. Doesn't matter... http://www.firearmstactical.com/pdf/fbi-hwfe.pdf Interesting article on what happens when a person is shot. Apparently, at least according to this article, not much. Lots of info about what happens and how the human body can stretch and rebound and how people who are shot can seemingly ignore that little inconvience and... The net result of this study is, once you shart shooting, DON'T STOP until you're absolutely sure of the outcome.......... Seems like good advice...!
If you put it between his eyes, the bullet itself won't knock him down, but that will be the end result of the encounter, no?